In-silico discovery of cancer-specific peptide-HLA complexes for targeted therapy

BMC Bioinformatics

Table 5 Predicted off-targets associated with top LAML and SKCM specific targets

	Tumor	Target	Target.gene	Off.target	IC₅₀	Gene	Normal.tissue.samples
1	LAML	LTSMWSPAV	UMODL1	LLKMWFPEV	21.60	DNAH7	Pituitary, Brain, LUAD, LUSC
2	SKCM	SLSVMSSNV	MAGEC2	MLAVMSYNT	206.18	SLC31A2	Blood, Salivary Gland, HNSC, LUAD
				MLYVMWKNV	137.41	OTOP2	Colon, S. Intestine, COAD, READ
				VLFVMWKNV	276.13	OTOP3	Esophagus, S. Intestine, STAD, HNSC

The table lists the off-target peptides, binding affinity (IC₅₀ in nanomolars) of peptide-HLA-A*02:01 complexes involving the off-target peptides, genes from which the off-target peptides were derived, and the essential, normal tissue types from GTEx and TCGA with high expression of the off-target peptides/genes. See Additional file 1 for description of TCGA tumor types

ISSN: 1471-2105