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Table 7 Predicted off-targets associated with target SLLMWITQC-HLA-A*02:01 derived from CTAG1A/NY-ESO-1

From: In-silico discovery of cancer-specific peptide-HLA complexes for targeted therapy

 

Off.target

DoS

IC50

Off.target.gene

Normal.tissue.samples

1

WLLPWICQC

6

66.56

GRID1

Brain, Thyroid, THCA, STAD

2

SLVKPITQL

5

206.18

ITGAM

Blood, Spleen, LUAD, LUSC

3

QLLMGIEQA

5

492.62

CABIN1

Blood, Blood Vessel, THCA, STAD

4

FLLHWITRG

5

335.50

NPC1L1

Liver, Small Intestine, STAD, LIHC

5

SILMYITSL

5

67.65

DMD

Muscle, Nerve, BLCA, STAD

6

PLLYNITQV

5

321.29

PHTF2

Muscle, Blood, HNSC, BLCA

7

TLLMVITGV

5

13.86

KIRREL2

Pancreas, Stomach, KIRP, KICH

8

LLTMHITQL

5

133.75

FBXL22

Colon, Blood Vessel, BLCA, STAD

9

FLLMFIKQL

5

37.51

LRBA

Pituitary, Skin, KIRC, KICH

10

MLLMKIQQL

5

62.71

SIMC1

Adrenal Gland, Muscle, ESCA, STAD

11

SLVYPITQV

5

30.87

BNC1

Salivary Gland, Esophagus, HNSC, STAD

12

RLLQVITQT

5

236.04

DNAH1

Blood, Liver, ESCA, LUAD

13

GLLNWITGA

5

13.06

VWA5B1

Pituitary, Bladder, KIRP, KIRC

14

SLSMGITLI

5

72.18

SLC16A14

Brain, Spleen, HNSC, LIHC

15

SALDQITQV

5

423.37

DNAH2

Lung, Brain, LUAD, LUSC

16

SILVWIFQA

5

52.18

SYNGR4

Brain, Pancreas, STAD, COAD

17

SLSKKITQV

5

59.73

CCDC38

Liver, Spleen, LIHC, HNSC

18

FLNRWITFC

5

52.74

IL2

Bladder, Small Intestine, STAD, BLCA

  1. The table lists the off-target peptides, degree of similarity of the off-target peptides with the target peptide, binding affinity (IC50 in nanomolars) of peptide-HLA-A*02:01 complexes involving the off-target peptides, genes from which the off-target peptides were derived, and the essential, normal tissue types from GTEx and TCGA with high expression of the off-target peptides/genes