Table 1 List of human KEGG pathways and Pfam clans used for benchmarking

hsa00040

Pentose and glucuronate interconversions

26

CL0099.10

ALDH-like

18

hsa00920

Sulfur metabolism

13

CL0106.10

6PGD_C

8

hsa00140

C21-Steroid homone metabolism

17

CL0417.1

BIR-like

9

hsa00290

Valine, leucine and isoleucine biosynthesis

11

CL0165.8

Cache

5

hsa00563

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

23

CL0149.9

CoA-acyltrans

7

hsa00670

One carbon pool by folate

16

CL0085.11

FAD_DHS

12

hsa00232

Caffeine metabolism

7

CL0076.9

FAD_Lum_binding

18

hsa03022

Basal transcription factors

38

CL0289.3

FBD

6

hsa03020

RNA polymerase

29

CL0119.10

Flavokinase

7

hsa04130

SNARE interactions in vesicular transport

38

CL0042.9

Flavoprotein

10

hsa03450

Non-homologous end-joining

14

hsa03430

Mismatch repair

23

hsa04950

Maturity onset diabetes of the young

25

Total #genes

280

100