An ensemble framework for identifying essential proteins

BMC Bioinformatics

Table 3 Degree distribution characteristics among the top 100 proteins ranked by different centrality measures and different ensemble methods

		BC	EnBC-a	CC	EnCC-a	DC	EnDC-a	EC	EnEC-a	SC	EnSC-a
PIN76K	Average degree	306.32	135.99	277.71	108.88	327.57	94.21	290.7	93.37	326.98	94.54
	Minimal degree	17	10	24	6	138	20	83	23	127	20
	#low_degree	-	1	-	7	-	89	-	60	-	83
	#EP	-	0	-	2	-	75	-	52	-	69
	Average node strength	0.07	0.42	0.08	0.47	0.12	0.57	0.2	0.58	0.2	0.54
PIN24K	Average degree	93.23	37.63	89.96	26.51	97.11	25.44	79.14	21.43	97.04	24.82
	Minimal degree	33	4	33	4	64	4	31	3	60	4
	#low_degree	-	62	-	76	-	95	-	78	-	93
	#EP	-	47	-	64	-	78	-	64	-	78
	Average node strength	0.07	0.35	0.06	0.45	0.07	0.5	0.05	0.53	0.05	0.39

#low_degree denotes the number of proteins out of the top 100 ranked proteins by an ensemble method whose degrees are less than the minimal degree of the top 100 proteins ranked by the corresponding centrality measure, and #EP the number of essential proteins out of the #low_degree proteins

ISSN: 1471-2105