Table 4 List of biological process GO terms significantly enriched and uniquely appearing in each topic for hESC differentiation

Topic 1

GO:0042769

DNA damage response, detection of DNA

3.5e-08

damage

GO:0090263

positive regulation of canonical Wnt

3.0e-07

signaling pathway

GO:0045814

negative regulation of gene expression,

4.1e-07

epigenetic

GO:0051084

de novo posttranslational protein folding

1.3e-06

Topic 2

GO:1900034

regulation of cellular response to heat

7.0e-08

GO:0051301

cell division

1.3e-07

GO:0044743

intracellular protein transmembrane import

2.1e-07

GO:0007077

mitotic nuclear envelope disassembly

7.2e-07

GO:1990542

mitochondrial transmembrane transport

9.7e-07

Topic 3

GO:0000281

mitotic cytokinesis

1.3e-07

Topic 4

GO:0010501

RNA secondary structure unwinding

1.5e-09

GO:0045596

negative regulation of cell differentiation

9.5e-09

GO:0048387

negative regulation of retinoic acid receptor

1.9e-08

signaling pathway

GO:0043066

negative regulation of apoptotic process

1.4e-07

GO:0006368

transcription elongation from RNA

2.0e-07

polymerase II promoter