TY - JOUR AU - Riemenschneider, Mona AU - Hummel, Thomas AU - Heider, Dominik PY - 2016 DA - 2016/08/22 TI - SHIVA - a web application for drug resistance and tropism testing in HIV JO - BMC Bioinformatics SP - 314 VL - 17 IS - 1 AB - Drug resistance testing is mandatory in antiretroviral therapy in human immunodeficiency virus (HIV) infected patients for successful treatment. The emergence of resistances against antiretroviral agents remains the major obstacle in inhibition of viral replication and thus to control infection. Due to the high mutation rate the virus is able to adapt rapidly under drug pressure leading to the evolution of resistant variants and finally to therapy failure. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-016-1179-2 DO - 10.1186/s12859-016-1179-2 ID - Riemenschneider2016 ER -