Skip to main content
Fig. 4 | BMC Bioinformatics

Fig. 4

From: KAOS: a new automated computational method for the identification of overexpressed genes

Fig. 4

Identification of known and new overexpressed kinases. Figure 1. Left panel shows gene expression level of a selected kinase in 917 cancer cell lines belonging to 24 different tumor types (CCLE data) as histogram. Tumor types are reported in different colors. The boxplot of the tissue-specific distribution of the kinase is reported in the right panel. Outlier samples are reported as black circl. a NTRK1 is generally expressed in hematopoietic and lymphoid and autonomic ganglia. No expression is observed in large intestine (colon), apart in KM12 colorectal cancer cell line, highlited as outlier in this tissue; b RET tyrosine kinase is generally expressed in tissues such as autonomic ganglia, haematopoietic tissues, but no expression is observed in thyroid tumors. In this tissue a dramatic expression of RET can be detected in TT papillary tumor cell line only, assigned as outlier by the tool; c ROS1 tyrosine kinase is typically poorly expressed apart in colon where HCC-78 lung cancer cell line stands out as a clear outlier; d FGFR4 is highly expressed in few breast cancer cell lines, among those MDA-MB-453 breast cancer cell line appear as highly overexpressed. e ZAP-70 tyrosine kinase can be observed in haematopoietic and lymphoid tissues only. No expression in breast cancer cell lines can be appreciated, with the exception of a significant overexpression of the gene in DU4475 breast cancer cell line

Back to article page