TY - JOUR AU - Manconi, Andrea AU - Moscatelli, Marco AU - Armano, Giuliano AU - Gnocchi, Matteo AU - Orro, Alessandro AU - Milanesi, Luciano PY - 2016 DA - 2016/11/08 TI - Removing duplicate reads using graphics processing units JO - BMC Bioinformatics SP - 346 VL - 17 IS - 12 AB - During library construction polymerase chain reaction is used to enrich the DNA before sequencing. Typically, this process generates duplicate read sequences. Removal of these artifacts is mandatory, as they can affect the correct interpretation of data in several analyses. Ideally, duplicate reads should be characterized by identical nucleotide sequences. However, due to sequencing errors, duplicates may also be nearly-identical. Removing nearly-identical duplicates can result in a notable computational effort. To deal with this challenge, we recently proposed a GPU method aimed at removing identical and nearly-identical duplicates generated with an Illumina platform. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-016-1192-5 DO - 10.1186/s12859-016-1192-5 ID - Manconi2016 ER -