Table 3 Z-scores for mixed alpha and beta class topologies in test set A: scores obtained for each topology for Blosum62, VT160_RA, and VTML200 matrices are shown in columns 2, 3, and 4

3.10.20

2.13

2.36

2.17

2.40

2.03

2.39

1.51

3.10.100

3.01

3.67

3.21

5.52

50.48

5.57

51.77

3.10.120

2.78

2.85

2.65

4.14

45.17

4.13

44.83

3.10.129

1.06

1.06

1.11

1.26

13.65

1.14

3.03

3.10.130

2.26

2.62

2.31

4.58

74.78

4.55

73.84

3.10.180

1.62

1.70

1.64

2.58

51.77

2.58

51.89

3.30.30

2.70

3.07

2.75

3.70

20.80

3.75

22.31

3.30.70

2.38

2.73

2.41

3.71

35.56

3.70

35.54

3.30.420

0.14

0.27

0.29

0.29

1.15

0.30

3.54

3.30.428

2.35

2.84

2.47

3.18

11.93

3.26

14.70

3.30.465

2.03

2.11

2.02

2.77

31.30

2.77

31.20

3.30.505

2.52

2.91

2.71

3.13

7.45

3.21

10.27

3.30.1050

2.87

3.16

2.74

3.47

9.85

3.34

5.55

3.30.1520

2.37

2.78

2.48

2.86

2.77

2.82

1.47

3.40.20

3.42

3.81

3.46

4.55

19.33

4.55

19.21

3.40.33

3.05

3.36

2.94

4.90

45.88

4.92

46.64

3.40.109

0.72

0.91

0.29

1.49

64.71

1.46

60.88

3.40.140

4.38

4.79

4.48

5.13

7.03

5.19

8.38

3.40.718

0.42

1.00

0.81

2.75

175.14

2.76

176.14

3.40.980

2.79

3.27

2.85

3.75

14.65

3.81

16.45

3.40.1050

0.07

0.32

0.02

2.23

595.27

2.14

567.18

3.60.21

0.92

0.84

0.79

1.69

83.39

1.67

80.72

3.70.10

3.29

3.77

3.29

4.34

15.15

4.31

14.41

3.90.79

1.86

2.05

1.84

3.01

46.42

2.89

40.90

3.90.730

5.25

5.62

5.34

5.69

1.34

5.67

1.01