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Table 5 The e-values of hits for PSI-blast search, profile HMM search and topology based PSI-blast search for topologies not yielding hits for PSI-blast, profile HMMs or both

From: Fold-specific sequence scoring improves protein sequence matching

 

E-values

Topology

Psi-blast

HMM

Topology psi-blast

1.10.150

1.00E-06

no hit

8.00E-18

1.10.238

3.00E-03

no hit

7.00E-38

1.10.533

no hit

3.30E-17

1.00E-30

1.10.1200

no hit

2.80E-05

5.00E-11

1.20.1250

no hit

1.10E-20

2.00E-44

2.40.128

no hit

3.00E-19

2.00E-59

2.60.40

no hit

no hit

1.00E-35

3.10.20

no hits

no hit

9.00E-25

3.30.420

no hit

5.00E-04

1.00E-48

3.30.450

3.00E-31

no hit

2.00E-52

3.40.630

no hit

no hit

1.00E-40

3.90.550

no hit

1.30E-06

1.00E-68

  1. The topology based PSI-blast clearly outperforms these popular conventional methods for not only cases where hits were not obtained by conventional methods but for all the cases tested (for results see Additional file 1)