Table 6 Network enrichment analysis of the repressed ESR gene set
|  | Gene set | n AB | μ 0 | log 10 (p-value) |
|---|---|---|---|---|
| Â | Go Slim BP sets: | Â | Â | Â |
1 | Cytoplasmic translation | 6878 | 2641.9 | <-300 |
2 | Ribosomal large subunit biogenesis | 3408 | 1097.8 | <-300 |
3 | Ribosomal small subunit biogenesis | 5861 | 2073.7 | <-300 |
4 | Ribosome assembly | 1782 | 621.9 | <-300 |
5 | RNA modification | 2944 | 1062.0 | <-300 |
6 | rRNA processing | 9187 | 3290.2 | <-300 |
7 | tRNA processing | 2037 | 901.0 | <-300 |
8 | Translational elongation | 1786 | 782.3 | –283.8 |
9 | Ribosomal subunit export from nucleus | 1420 | 561.4 | –281.8 |
10 | Translational initiation | 939 | 462.5 | –112.1 |
11 | Transcription from RNA polymerase III promoter | 565 | 228.4 | –107.7 |
12 | SnoRNA processing | 634 | 303.3 | –82.0 |
13 | Regulation of translation | 1952 | 1328.6 | –73.5 |
14 | DNA-dependent transcription, termination | 774 | 447.0 | –57.5 |
15 | Transcription from RNA polymerase I promoter | 1005 | 646.4 | –49.5 |
16 | Protein alkylation | 1063 | 759.4 | –31.4 |
17 | tRNA aminoacylation for protein translation | 400 | 233.1 | –29.4 |
18 | Peptidyl-amino acid modification | 1088 | 883.0 | –13.2 |
19 | Nuclear transport | 3154 | 2003.5 | –162.4 |
20 | Organelle assembly | 2090 | 1362.7 | –96.1 |
21 | Nucleobase-containing compound transport | 1453 | 1155.4 | –20.8 |
22 | Cytokinesis | 1024 | 806.9 | –16.0 |
23 | Vitamin metabolic process | 325 | 274.0 | –3.1 |
| Â | KEGG pathways: | Â | Â | Â |
24 | Ribosome biogenesis in eukaryotes | 9824 | 3661.0 | <-300 |
25 | Ribosome | 18640 | 8731.7 | <-300 |
26 | RNA polymerase | 3057 | 1541.2 | <-300 |
27 | RNA transport | 4341 | 2906.4 | –177.6 |
28 | Aminoacyl-tRNA biosynthesis | 1433 | 960.9 | –58.2 |
29 | RNA degradation | 2560 | 1939.3 | –51.9 |
30 | mRNA surveillance pathway | 1768 | 1413.5 | –24.0 |
31 | Pentose phosphate pathway | 1126 | 947.1 | –9.7 |
32 | Spliceosome | 2649 | 2523.6 | –2.3 |
33 | Purine metabolism | 5579 | 3623.0 | –263.6 |
34 | Pyrimidine metabolism | 4541 | 2884.5 | –234.9 |
35 | Cyanoamino acid metabolism | 218 | 158.8 | –6.3 |
36 | One carbon pool by folate | 541 | 392.5 | –15.0 |
37 | Sulfur relay system | 238 | 196.5 | –2.9 |
38 | Carbapenem biosynthesis | 117 | 89.8 | –2.7 |