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Table 8 Network enrichment analysis of the induced ESR gene set (KEGG pathways)

From: NEAT: an efficient network enrichment analysis test

  KEGG pathway n AB μ 0 log 10 (p-value)
1 Starch and sucrose metabolism 1436 394.2 <-300
2 Pentose and glucuronate interconversions 414 110.7 –119.9
3 Glycolysis/Gluconeogenesis 1235 616.3 –116.5
4 Fructose and mannose metabolism 562 200.0 –106.7
5 Galactose metabolism 511 173.9 –104.5
6 Amino sugar and nucleotide sugar metabolism 567 264.2 –63.4
7 Other glycan degradation 79 11.7 –44.2
8 Pyruvate metabolism 633 355.9 –42.8
9 Propanoate metabolism 189 107.3 –12.9
10 Glycerolipid metabolism 444 172.1 –72.7
11 Peroxisome 633 313.3 –61.2
12 Fatty acid degradation 419 215.0 –37.2
13 Arachidonic acid metabolism 117 36.7 –28.1
14 Sphingolipid metabolism 227 103.6 –27.3
15 Glycerophospholipid metabolism 450 270.9 –24.5
16 alpha-Linolenic acid metabolism 69 27.1 –11.7
17 Fatty acid elongation 138 75.3 –10.8
18 Biosynthesis of unsaturated fatty acids 134 103.9 –2.5
19 Glutathione metabolism 467 204.8 –59.9
20 Citrate cycle (TCA cycle) 487 267.3 –35.6
21 Ubiquinone and other terpenoid-quinone biosynthesis 96 41.8 –13.1
22 Protein processing in endoplasmic reticulum 1121 866.0 –17.4
23 Longevity regulating pathway 987 544.0 –70.6
24 beta-Alanine metabolism 397 104.0 –118.0
25 Taurine and hypotaurine metabolism 132 24.3 –59.4
26 Tyrosine metabolism 382 163.5 –51.8
27 Tryptophan metabolism 292 113.3 –48.2
28 Valine, leucine and isoleucine degradation 276 107.5 –45.3
29 Alanine, aspartate and glutamate metabolism 488 262.2 –38.0
30 Histidine metabolism 267 127.4 –28.8
31 Arginine and proline metabolism 301 154.3 –27.0
32 Lysine degradation 294 150.4 –26.6
33 Phenylalanine metabolism 171 71.4 –25.0
34 Glycine, serine and threonine metabolism 350 264.3 –6.7
35 Cysteine and methionine metabolism 338 285.3 –2.8
36 Arginine biosynthesis 167 134.0 –2.4
37 Butanoate metabolism 460 84.8 –202.8
38 Pentose phosphate pathway 604 288.0 –64.0
39 Regulation of autophagy 303 126.7 –43.3
40 Insulin resistance 337 172.8 –30.1
41 Glyoxylate and dicarboxylate metabolism 368 201.6 –27.3
42 Methane metabolism 435 254.2 –26.2
43 Nicotinate and nicotinamide metabolism 154 99.8 –6.7
44 Nitrogen metabolism 88 52.8 –5.4
45 Thiamine metabolism 57 32.9 –4.1
46 Selenocompound metabolism 122 89.3 –3.2
47 Sulfur metabolism 133 105.3 –2.2
  1. The table lists the 47 KEGG pathways which the set of induced ESR genes is found to be over-enriched with at 1 % significance level