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Table 8 Network enrichment analysis of the induced ESR gene set (KEGG pathways)

From: NEAT: an efficient network enrichment analysis test

 

KEGG pathway

n AB

μ 0

log 10 (p-value)

1

Starch and sucrose metabolism

1436

394.2

<-300

2

Pentose and glucuronate interconversions

414

110.7

–119.9

3

Glycolysis/Gluconeogenesis

1235

616.3

–116.5

4

Fructose and mannose metabolism

562

200.0

–106.7

5

Galactose metabolism

511

173.9

–104.5

6

Amino sugar and nucleotide sugar metabolism

567

264.2

–63.4

7

Other glycan degradation

79

11.7

–44.2

8

Pyruvate metabolism

633

355.9

–42.8

9

Propanoate metabolism

189

107.3

–12.9

10

Glycerolipid metabolism

444

172.1

–72.7

11

Peroxisome

633

313.3

–61.2

12

Fatty acid degradation

419

215.0

–37.2

13

Arachidonic acid metabolism

117

36.7

–28.1

14

Sphingolipid metabolism

227

103.6

–27.3

15

Glycerophospholipid metabolism

450

270.9

–24.5

16

alpha-Linolenic acid metabolism

69

27.1

–11.7

17

Fatty acid elongation

138

75.3

–10.8

18

Biosynthesis of unsaturated fatty acids

134

103.9

–2.5

19

Glutathione metabolism

467

204.8

–59.9

20

Citrate cycle (TCA cycle)

487

267.3

–35.6

21

Ubiquinone and other terpenoid-quinone biosynthesis

96

41.8

–13.1

22

Protein processing in endoplasmic reticulum

1121

866.0

–17.4

23

Longevity regulating pathway

987

544.0

–70.6

24

beta-Alanine metabolism

397

104.0

–118.0

25

Taurine and hypotaurine metabolism

132

24.3

–59.4

26

Tyrosine metabolism

382

163.5

–51.8

27

Tryptophan metabolism

292

113.3

–48.2

28

Valine, leucine and isoleucine degradation

276

107.5

–45.3

29

Alanine, aspartate and glutamate metabolism

488

262.2

–38.0

30

Histidine metabolism

267

127.4

–28.8

31

Arginine and proline metabolism

301

154.3

–27.0

32

Lysine degradation

294

150.4

–26.6

33

Phenylalanine metabolism

171

71.4

–25.0

34

Glycine, serine and threonine metabolism

350

264.3

–6.7

35

Cysteine and methionine metabolism

338

285.3

–2.8

36

Arginine biosynthesis

167

134.0

–2.4

37

Butanoate metabolism

460

84.8

–202.8

38

Pentose phosphate pathway

604

288.0

–64.0

39

Regulation of autophagy

303

126.7

–43.3

40

Insulin resistance

337

172.8

–30.1

41

Glyoxylate and dicarboxylate metabolism

368

201.6

–27.3

42

Methane metabolism

435

254.2

–26.2

43

Nicotinate and nicotinamide metabolism

154

99.8

–6.7

44

Nitrogen metabolism

88

52.8

–5.4

45

Thiamine metabolism

57

32.9

–4.1

46

Selenocompound metabolism

122

89.3

–3.2

47

Sulfur metabolism

133

105.3

–2.2

  1. The table lists the 47 KEGG pathways which the set of induced ESR genes is found to be over-enriched with at 1 % significance level