Fig. 1

The construction of tissue-specific networks and the classification of MDS proteins. Following the method of [42], molecular expression profiles across 16 human tissues are obtained by consolidating three types of data (GNF [20], HPA [24] and RNA-seq [41]). In parallel, high-quality binary interactions for H. sapiens are collected from the HINT database [40]. Tissue-specific networks are constructed by removing proteins that are not expressed in the corresponding tissues from the global network. Then the CI-MDS model is applied to each tissue-specific network and proteins are classified into MDS proteins and Non-MDS (NMDS) proteins. MDS proteins are further categorized into HouseKeeping MDS (HK-MDS) proteins and Tissue-Specific MDS (TS-MDS) proteins based on the number of tissues in which they are expressed and identified as MDS proteins