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Table 2 Biological centrality of different types of MDS proteins

From: Comparative analysis of housekeeping and tissue-specific driver nodes in human protein interaction networks

 

MDS (2,265)

TS-MDS (125)

HK-MDS (872)

Biologically central proteins (No.)

No (pct) of BC

p-value

No (pct) of BC

p-value

No (pct) of BC

p-value

Essential genes (1,911)

638 (28.2 %)

5.4E-31

23 (18.4 %)

9.1E-01

283 (32.5 %)

1.0E-21

Ageing genes (267)

140 (6.2 %)

5.0E-26

4 (3.2 %)

5.8E-01

83 (9.5 %)

8.7E-26

Virus-targeted proteins (1,934)

646 (28.5 %)

1.2E-31

21 (16.8 %)

5.0E-01

327 (37.5 %)

6.4E-38

Transcription factors (156)

64 (2.8 %)

4.3E-07

4 (3.2 %)

1.4E-01

38 (4.4 %)

5.4E-09

Protein kinases (392)

146 (6.4 %)

1.2E-10

3 (2.4 %)

4.9E-01

62 (7.1 %)

6.8E-06

Disease-related genes (2,022)

594 (26.2 %)

1.1E-13

45 (36.0 %)

7.5E-05

223 (25.6 %)

1.9E-04

Cancer-related genes (791)

234 (10.3 %)

8.4E-06

17 (13.6 %)

2.9E-02

76 (8.7 %)

4.3E-01