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Table 2 Biological centrality of different types of MDS proteins

From: Comparative analysis of housekeeping and tissue-specific driver nodes in human protein interaction networks

  MDS (2,265) TS-MDS (125) HK-MDS (872)
Biologically central proteins (No.) No (pct) of BC p-value No (pct) of BC p-value No (pct) of BC p-value
Essential genes (1,911) 638 (28.2 %) 5.4E-31 23 (18.4 %) 9.1E-01 283 (32.5 %) 1.0E-21
Ageing genes (267) 140 (6.2 %) 5.0E-26 4 (3.2 %) 5.8E-01 83 (9.5 %) 8.7E-26
Virus-targeted proteins (1,934) 646 (28.5 %) 1.2E-31 21 (16.8 %) 5.0E-01 327 (37.5 %) 6.4E-38
Transcription factors (156) 64 (2.8 %) 4.3E-07 4 (3.2 %) 1.4E-01 38 (4.4 %) 5.4E-09
Protein kinases (392) 146 (6.4 %) 1.2E-10 3 (2.4 %) 4.9E-01 62 (7.1 %) 6.8E-06
Disease-related genes (2,022) 594 (26.2 %) 1.1E-13 45 (36.0 %) 7.5E-05 223 (25.6 %) 1.9E-04
Cancer-related genes (791) 234 (10.3 %) 8.4E-06 17 (13.6 %) 2.9E-02 76 (8.7 %) 4.3E-01