Table 1 Differences in gene interactions between original and trained Bonzanni and Krumsiek models
From: BTR: training asynchronous Boolean models using single-cell expression data
Models | Gene interactions | Suggested modifications to original model |
|---|---|---|
Bonzanni | Gata2 and Hhex inhibits Gata2 | Deletion |
Scl and Gata2 activates Scl | Deletion | |
Fli1 and Gata2 activates Scl | Deletion | |
Gata2 and Scl activates Fli1 | Deletion | |
Fli1 activates Runx1 | Deletion | |
Fli1 activates Erg | Deletion | |
Erg activates Erg | Deletion | |
Gata1 and Fog1 inhibits Gata2 | Deletion | |
Sfpi1 and Gata1 inhibits Gata1 | Deletion | |
Sfpi1 activates Sfpi1 | Deletion | |
Sfpi1 and Erg activates Sfpi1 | Addition | |
Hhex and Runx1 inhibits Gata2 | Addition | |
Eto2 and Hhex inhibits Gata2 | Addition | |
Sfpi1 activates Hhex | Addition | |
Gata1 inhibits Gata2 | Addition | |
Fog1 inhibits Smad6 | Addition | |
Fog1 inhibits Fli1 | Addition | |
Eto2 activates Gata1 | Addition | |
Eto2 activates Fog1 | Addition | |
Hhex inhibits Gata1 | Addition | |
Hhex activates Eto2 | Addition | |
Hhex inhibits Erg | Addition | |
Fli1 inhibits Runx1 | Addition | |
Krumsiek | Cebpa activates Gfi1 | Deletion |
Gata2 inhibits Sfpi1 | Deletion | |
Sfpi1 inhibits Gata2 | Deletion | |
Gfi1 activates Fli1 | Activation | |
Cebpa activates Fli1 | Activation | |
Fli1 and Gata2 inhibits Sfpi1 | Activation | |
Fli1 and Sfpi1 inhibits Gata2 | Activation | |
Cebpa inhibits Gata1 | Activation | |
EgrNab activates Ldb1 | Activation | |
cJun activates Ldb1 | Activation | |
Ldb1 inhibits Gata1 | Activation | |
Gata2 activates Ldb1 | Activation | |
Ldb1 activates Lmo2 | Activation | |
Ldb1 and Gata2 activates Lmo2 | Activation | |
Lmo2 inhibits Gata1 | Activation |