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Table 2 A comparison of ASE call rates for three different approaches: a filtering methods, mapping to two parental genomes and our normalization approach

From: A haplotype-based normalization technique for the analysis and detection of allele specific expression

Mapping procedure Control Method True Positives False Positives True Negatives False Negatives Sensitivity Specificity Precision
TH2_5MM Normalized 142.28 19.80 11737.80 36.80 79.42 % 99.83 % 87.69 %
TH2_5MM Two Genomes 144.96 21.84 11737.68 34.44 80.84 % 99.81 % 86.85 %
TH2_5MM Filtered 117.44 46.12 11711.48 61.64 65.71 % 99.61 % 71.77 %
STAR (No clip) Normalized 147.40 29.00 11729.24 31.80 82.28 % 99.75 % 83.52 %
STAR (No clip) Two Genomes 152.24 22.28 11724.96 27.16 84.80 % 99.81 % 87.17 %
STAR (No clip) Filtered 122.68 43.72 11714.52 56.52 68.53 % 99.63 % 73.70 %