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Table 3 Running time (seconds) for warm-start versus cold-started FVA in quad-precision using Quad MINOS (two LPs are run for each reaction)

From: solveME: fast and reliable solution of nonlinear ME models

Model

Reactions

Warm-start

Cold-start

Speed-up

E. coli ME (reduced)

16126

11.2 h

>670 h

60 ×

T. maritima ME [3]

17535

78 h

>1940 h

25×