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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Sierra platinum: a fast and robust peak-caller for replicated ChIP-seq experiments with visual quality-control and -steering

Fig. 1

Overview of the multiple-replicate peak-calling process showing the basic steps of multiple-replicate peak-calling for Sierra Platinum, PePr, MACS-CR (combine replicates approach using MACS as single-experiment peak-caller), and MACS-SA (combine peaks approach using MACS as single-experiment peak-caller). All peak-caller extract the parameters of the underlying model (squares) from the background data (dark circles) and use it to calculate p-values (pentagons) indicating how significantly enriched the experiment (light circles) is. Based on the p-values, peaks (triangles) are calculated. Quality control (magnifier) is provided usually alongside with the peaks. Only Sierra allows to examine the quality during the peak-calling process, while all other methods only allow to examine the quality of the peaks obtained

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