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Fig. 3 | BMC Bioinformatics

Fig. 3

From: From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration

Fig. 3

Framework to uncover co-morbidity associated mechanisms. The figure depicts first the use of gene-disease associations from multiple disease ontologies/nomenclatures and multiple disease-gene databases (and mappings from UMLS) to generate mapping1 (red block: 1) and its extension through PPI associations to generate mapping2 (red block: 2). Secondly, the figure depicts the computation of Disease Groups (red block: 3). Finally, the figure depicts the mapping of gene-DGs that results in mapping1_DG and mapping2_DG (red block: 4) and their pathway extensions (red block: 5)

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BMC Bioinformatics

ISSN: 1471-2105

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