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Table 1 Covariance structure examples

From: Unsupervised gene set testing based on random matrix theory

Name

Model

Self-contained

Competitive

Identity

\( \boldsymbol {\Sigma } =\left [\begin {array}{cc} I & 0 \\ 0 & I \\ \end {array}\right ]\)

Accept H 0

Accept H 0

Scaled identity

\( \boldsymbol {\Sigma } = \left [\begin {array}{cc} \alpha I & 0 \\ 0 & \alpha I \\ \end {array}\right ]\)

Reject H 0

Accept H 0

Single block

\( \boldsymbol {\Sigma } = \left [\begin {array}{cc} \rho & 0 \\ 0 & I \\ \end {array}\right ]\)

Reject H 0

Reject H 0

Multi-block

\(\boldsymbol {\Sigma } = \left [\begin {array}{cc} \left [\begin {array}{cc} \rho & 0 \\ 0 & \rho \\ \end {array}\right ] & 0 \\ 0 & I \\ \end {array}\right ]\)

Reject H 0

Reject H 0

Anti-correlated multi-block

\( \boldsymbol {\Sigma } = \left [\begin {array}{cc} \left [\begin {array}{cc} \rho & -\rho \\ -\rho & \rho \\ \end {array}\right ] & 0 \\ 0 & I \\ \end {array}\right ] \)

Reject H 0

Reject H 0

Inverted single block

\( \boldsymbol {\Sigma } = \left [\begin {array}{cc} I & 0 \\ 0 & \rho \\ \end {array}\right ] \)

Accept H 0

Accept H 0

Repeated single block

\( \boldsymbol {\Sigma } = \left [\begin {array}{cc} \rho & 0 \\ 0 & \rho \\ \end {array}\right ] \)

Reject H 0

Reject H 0

Compound symmetry

\( \boldsymbol {\Sigma } = \left [\begin {array}{cc} \rho & \rho \\ \rho & \rho \\ \end {array}\right ]\)

Reject H 0

Accept H 0

  1. Examples where the self-contained and competitive tests give different answers are in bold. For the inverted single block structure, a two-sided competitive null would be rejected whereas the one-sided competitive H A would be accepted. For the repeated block structure, H 0 will be rejected since a random sample of g genes from among all p genes will likely include some pairs with 0 covariance