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Table 2 Simulation designs for type I error

From: Unsupervised gene set testing based on random matrix theory

Type I error design #

Covariance structure

g

p

n

σ 2

ρ

MVN-1

Identity

10

100

100

1

0

MVN-2

Scaled Identity

10

100

100

2

0

MVN-3

Compound symmetry

10

100

20

1

0.1

MVN-4

Compound symmetry

10

100

50

1

0.1

MVN-5

Compound symmetry

10

100

100

1

0.1

MVN-6

Compound symmetry

10

100

100

2

0.1

MVN-7

Compound symmetry

10

100

100

1

0.2

Binomial-1

Compound symmetry

10

100

100

0.375

0.1

  1. Simulation design models for assessing type I error control using a multivariate normal distribution (MVN-1 thru MVN-7) or a multivariate binomial (n=2, p=0.25) distribution (Bionomial-1) for x