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Fig. 4 | BMC Bioinformatics

Fig. 4

From: ChARM: Discovery of combinatorial chromatin modification patterns in hepatitis B virus X-transformed mouse liver cancer using association rule mining

Fig. 4

Epigenetic profiles of P155. a Differential changes of histone modifications between HBx TG and normal livers in Pattern 155. The plotted data are the dRES values summed over the member genes of Pattern 155 (50-bp interval). Promoter regions are divided into three regions relative to TSS: proximal (P: −200 to 500 bp), intermediate (I: −1000 to −200 bp) and distal (D: −1500 to −1,000 bp). Vertical grey lines in each figure represent the three promoter regions. b, c and d) A comparison between HBx and normal livers for (b) H3K4Me3, c H3K27Me3, and (d) H3K36Me3. b shows that H3K4Me3 was hypermethylated near the TSS regions in normal livers, whereas it underwent demethylation in HBx, displaying a strong negative peak in (a). e and f The changes in histone modification for (e) HCPs (242 transcripts) and (f) LCPs (43 transcripts) in Pattern 155. Blue bars in represent regions matched with Pattern 155. dRES changes of H3K4Me3, H3K27Me3 and H3K36Me3 from (a), (e) and (f) are coloured green, red, purple, respectively. dk4, dk27 and dk36 stand for H3K4Me3, H3K27Me3 and H3K36Me3, respectively

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BMC Bioinformatics

ISSN: 1471-2105

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