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Fig. 5 | BMC Bioinformatics

Fig. 5

From: ChARM: Discovery of combinatorial chromatin modification patterns in hepatitis B virus X-transformed mouse liver cancer using association rule mining

Fig. 5

CpG ratio bias in Pattern 155. CpG ratio distributions in promoters and gene bodies for P155 (red), G155 (green), and all transcripts (grey). a In promoters, a high peak for the CpG ratio in P155 was observed where the CpG ratio was > 0.6, whereas two peaks were found for all transcripts, one in the low CpG ratio and one in high CpG ratio. b The CpG ratio distribution in gene bodies: 57 % of the G155 shows high CpG content (CpG ratio > 0.5). All transcripts and P155 show high peaks in the low CpG ratio (<0.4). (C and D) CpG ratio distributions alongside promoter regions for all transcripts: c HCPs (Additional file 3: Figure S4) and (d) LCPs of P155. e The proportion of 200 base pair intervals matched to Pattern 155 that corresponds to HCPs, ICPs, and LCPs alongside promoter regions. HCPs are more likely to match in intermediate or distal promoter regions, whereas LCPs are likely to match in proximal promoter regions around the TSS

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