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Table 2 All histone modifications considered in this study. The remaining histone modifications available from ENCODE are unsuitable for this study as they assert their functional role in non-promoter regions (e.g. H3K36me3 in the 3′-UTR)

From: Distributed gene expression modelling for exploring variability in epigenetic function

Histone modification

Regulatory role

Chromatin localisation

H2A.Z

Bivalency

Euchromatin

H3K4me3

Activator/Bivalency

Euchromatin

H3K9ac

Activator

Euchromatin

H3K9me3

Repressor

Constitutive heterochromatin

H3K27ac

Activator

Euchromatin

H3K27me3

Repressor/Bivalency

Facultative heterochromatin