LNDriver: identifying driver genes by integrating mutation and expression data based on gene-gene interaction network

Table 3 The rare driver genes in KIRC

Rank	Gene	Cases with mutations	Mutation frequency (%)	p-value	CGC genes
3	SRC	2	0.481928	0.001378	NO
5	EGFR	7	1.686747	0.003100	YES
6	EP300	6	1.445783	0.003214	YES
7	CHD3	4	0.963855	0.004018	NO
8	EWSR1	2	0.481928	0.00551	YES
9	ATF7IP	5	1.204819	0.007462	NO
11	RB1	1	0.240964	0.010332	YES
12	NCOA3	5	1.204819	0.011135	NO
13	PRKCD	2	0.481928	0.011135	NO
14	CREBBP	4	0.963855	0.012513	YES
15	DDX20	4	0.963855	0.012513	NO
16	SMAD9	1	0.240964	0.013546	NO
17	KDR	5	1.204819	0.016186	YES
19	PPARG	1	0.240964	0.018138	YES
21	ATXN1	2	0.481928	0.021008	NO
22	HDAC1	2	0.481928	0.021008	NO
23	PLG	5	1.204819	0.021008	NO
24	CDKN2A	5	1.204819	0.023533	YES
25	MET	3	0.722892	0.023533	YES
26	EIF6	1	0.240964	0.027322	NO
27	JAK2	5	1.204819	0.027322	YES
29	PCNA	3	0.722892	0.032717	NO
30	ARF6	1	0.240964	0.039031	NO
31	FRS2	2	0.481928	0.039031	NO
32	SETDB1	4	0.963855	0.039031	NO
33	NOS1	8	1.927711	0.044886	NO
34	PPP2R1A	2	0.481928	0.044886	YES
35	RAB5A	1	0.240964	0.044886	NO
36	SVIL	7	1.686747	0.044886	NO

ISSN: 1471-2105