Skip to main content

Table 4 The rare driver genes in THCA

From: LNDriver: identifying driver genes by integrating mutation and expression data based on gene-gene interaction network

Rank

Gene

Cases with mutations

Mutation frequency (%)

p-value

CGC genes

3

RB1

6

1.385681

0.000101

YES

4

TP53

3

0.692841

0.000101

YES

6

PRKACA

2

0.461894

0.002121

NO

7

PTK2B

2

0.461894

0.004141

NO

8

PIK3R1

2

0.461894

0.005858

YES

9

EP300

3

0.692841

0.006868

YES

10

PTPN6

1

0.230947

0.008484

NO

11

CASP3

1

0.230947

0.009191

NO

12

JAK2

2

0.461894

0.009191

YES

14

YWHAG

1

0.230947

0.009191

NO

15

CDKN1A

1

0.230947

0.009696

NO

16

PTEN

6

1.385681

0.010706

YES

17

CTNNB1

4

0.923788

0.018079

YES

18

ACTB

1

0.230947

0.020099

NO

19

PML

8

1.847575

0.020099

YES

20

ATM

5

1.154734

0.022725

YES

21

HSP90AA1

1

0.230947

0.022725

YES

22

SMAD3

1

0.230947

0.026462

NO

24

FLNC

5

1.154734

0.035754

NO

25

BRCA1

6

1.385681

0.041713

YES

26

CHD3

4

0.923788

0.041713

NO

27

CHEK2

7

1.616628

0.041713

YES

28

GRIN2B

5

1.154734

0.041713

NO

29

NEDD4

5

1.154734

0.041713

NO

30

PIAS4

2

0.461894

0.041713

NO

31

RASA1

2

0.461894

0.041713

NO

32

VAV1

1

0.230947

0.041713

NO

33

ACTA1

1

0.230947

0.048783

NO

34

SP1

1

0.230947

0.048783

NO