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Fig. 2 | BMC Bioinformatics

Fig. 2

From: A network-based pathway-expanding approach for pathway analysis

Fig. 2

Construction of the weighted gene-gene interaction network (the edge width reflects weight size in the weighted gene-gene interaction network). The PPI network comes from I2D, the co-expression weighted network is from gene expression profiling, and the weight of each pair of genes is calculated by Pearson’s correlation coefficient. Finally, the PPI network and the co-expression weighted network are merged into the weighted gene-gene interaction network. We obtain two weighted gene-gene interaction networks under two phenotype datasets (tumor and normal)

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