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Table 4 Predictive performance of physicochemical property features for the four benchmark datasets

From: Prediction of HIV-1 protease cleavage site using a combination of sequence, structural, and physicochemical features

Features

DT

LR

ANN

Acc.(%)

AUC

Acc.(%)

AUC

Acc.(%)

AUC

746 Dataset

 Hydrophobicity

75.6

0.735

83.7

0.956

89.1

0.968 *

 Steric property

89.1

0.929

86.4

0.941

81.0

0.932

 Polarizability

81.0

0.815

83.7

0.953

83.7

0.947

 Isoelectric point

81.0

0.865

86.4

0.953

83.7

0.953

 Polarity

83.7

0.838

83.7

0.912

86.4

0.909

 Volume

83.7

0.838

54.0

0.500

54.0

0.500

 Phy_All

84.9

0.882

93.6

0.885

97.3

0.953

1625 Dataset

 Hydrophobicity

87.8

0.849

84.1

0.896

86.5

0.874

 Steric property

91.4

0.897

85.3

0.896

91.4

0.934

 Polarizability

93.9

0.914

87.8

0.936

96.3

0.957

 Isoelectric point

91.4

0.918

82.9

0.914

93.9

0.968

 Polarity

86.5

0.847

87.8

0.904

89.0

0.919

 Volume

92.6

0.896

89.0

0.933

93.9

0.974

 Phy_All

92.7

0.882

92.7

0.921

92.7

0.944

Schilling Dataset

 Hydrophobicity

87.7

0.708

89.5

0.862

89.5

0.863

 Steric property

88.3

0.721

86.5

0.837

88.3

0.843

 Polarizability

89.5

0.683

89.5

0.854

90.8

0.853

 Isoelectric point

88.3

0.733

87.7

0.858

89.5

0.860

 Polarity

87.1

0.500

87.1

0.860

88.3

0.865

 Volume

88.9

0.622

88.3

0.847

88.3

0.810

 Phy_All

88.9

0.593

89.5

0.876

85.2

0.863

Impens Dataset

 Hydrophobicity

85.1

0.500

80.8

0.686

87.2

0.886

 Steric property

89.3

0.845

82.9

0.825

89.3

0.893

 Polarizability

85.1

0.500

85.1

0.864

89.3

0.943

 Isoelectric point

85.1

0.500

78.7

0.850

93.6

0.982

 Polarity

85.1

0.500

85.1

0.743

82.9

0.682

 Volume

85.1

0.500

85.1

0.736

80.8

0.500

 Phy_All

91.5

0.839

82.9

0.796

87.2

0.839

  1. *The best accuracy and AUC in each dataset are underlined