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Table 4 Predictive performance of physicochemical property features for the four benchmark datasets

From: Prediction of HIV-1 protease cleavage site using a combination of sequence, structural, and physicochemical features

Features DT LR ANN
Acc.(%) AUC Acc.(%) AUC Acc.(%) AUC
746 Dataset
 Hydrophobicity 75.6 0.735 83.7 0.956 89.1 0.968 *
 Steric property 89.1 0.929 86.4 0.941 81.0 0.932
 Polarizability 81.0 0.815 83.7 0.953 83.7 0.947
 Isoelectric point 81.0 0.865 86.4 0.953 83.7 0.953
 Polarity 83.7 0.838 83.7 0.912 86.4 0.909
 Volume 83.7 0.838 54.0 0.500 54.0 0.500
 Phy_All 84.9 0.882 93.6 0.885 97.3 0.953
1625 Dataset
 Hydrophobicity 87.8 0.849 84.1 0.896 86.5 0.874
 Steric property 91.4 0.897 85.3 0.896 91.4 0.934
 Polarizability 93.9 0.914 87.8 0.936 96.3 0.957
 Isoelectric point 91.4 0.918 82.9 0.914 93.9 0.968
 Polarity 86.5 0.847 87.8 0.904 89.0 0.919
 Volume 92.6 0.896 89.0 0.933 93.9 0.974
 Phy_All 92.7 0.882 92.7 0.921 92.7 0.944
Schilling Dataset
 Hydrophobicity 87.7 0.708 89.5 0.862 89.5 0.863
 Steric property 88.3 0.721 86.5 0.837 88.3 0.843
 Polarizability 89.5 0.683 89.5 0.854 90.8 0.853
 Isoelectric point 88.3 0.733 87.7 0.858 89.5 0.860
 Polarity 87.1 0.500 87.1 0.860 88.3 0.865
 Volume 88.9 0.622 88.3 0.847 88.3 0.810
 Phy_All 88.9 0.593 89.5 0.876 85.2 0.863
Impens Dataset
 Hydrophobicity 85.1 0.500 80.8 0.686 87.2 0.886
 Steric property 89.3 0.845 82.9 0.825 89.3 0.893
 Polarizability 85.1 0.500 85.1 0.864 89.3 0.943
 Isoelectric point 85.1 0.500 78.7 0.850 93.6 0.982
 Polarity 85.1 0.500 85.1 0.743 82.9 0.682
 Volume 85.1 0.500 85.1 0.736 80.8 0.500
 Phy_All 91.5 0.839 82.9 0.796 87.2 0.839
  1. *The best accuracy and AUC in each dataset are underlined