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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Identification of recurrent combinatorial patterns of chromatin modifications at promoters across various tissue types

Fig. 2

Value of λ is empirically selected by comparing the two affinity matrices generated based on data from two different cell lines. a Heatmaps of the affinity matrices (12 chromatin modifications) for datasets of GM12878 and HSMM cell lines. There are 66 pairs of chromatin modifications. b The affinity values are plotted in the scatter plot to compare the 66 pairs of chromatin modifications. The X coordinate is from cell line GM12878, the Y coordinate is from cell line HSMM. If the affinities between chromatin modifications are close, the correlation (PCC) between X and Y axis should be relatively high. c Changes of PCC based on different values of λ. The λ that associates with the highest PCC is then used (λ = 1.3E5). d As the value of λ increases, the sparsity of the two affinity matrices also increases

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BMC Bioinformatics

ISSN: 1471-2105

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