Table 6 Performance of all methods on the “hard” target proteins over each type of ligand
From: Protein ligand-specific binding residue predictions by an ensemble classifier
Ligand | Na | Method | Accuracy (%) | Sensitivity (%) | Specificity (%) | MCC (%)b |
|---|---|---|---|---|---|---|
CU | 3 | TargetCom | 98.76 | 16.67 | 1 | 23.42 |
COACH | 98.76 | 16.67 | 1 | 23.42 | ||
S-SITE | 98.76 | 33.33 | 99.56 | 27.04 | ||
TargetSeq | 98.33 | 0 | 1 | 0 | ||
COFACTOR | 98.33 | 0 | 1 | 0 | ||
TM-SITE | 98.33 | 0 | 1 | 0 | ||
FE | 3 | TargetCom | 98.48 | 16.67 | 1 | 23.39 |
COACH | 98.48 | 16.67 | 1 | 23.39 | ||
S-SITE | 98.73 | 25.00 | 1 | 28.76 | ||
TargetSeq | 98.26 | 12.5 | 99.9 | 20.03 | ||
COFACTOR | 97.98 | 0 | 1 | 0 | ||
TM-SITE | 97.98 | 0 | 1 | 0 | ||
ZN | 30 | TargetCom | 98.38 | 40.63 | 99.42 | 37.49 |
COACH | 97.65 | 40.91 | 98.66 | 31.86 | ||
S-SITE | 97.43 | 43.32 | 98.37 | 33.51 | ||
TargetSeq | 97.97 | 7.02 | 99.68 | 11.43 | ||
COFACTOR | 98.14 | 0 | 1 | 0 | ||
TM-SITE | 97.99 | 0 | 99.85 | −0.15 | ||
SO4 | 5 | TargetCom | 97.11 | 6.67 | 99.61 | 7.61 |
COACH | 97.02 | 6.67 | 99.51 | 7.08 | ||
S-SITE | 97.11 | 0 | 1 | 0 | ||
TargetSeq | 97.11 | 0 | 1 | 0 | ||
COFACTOR | 97.39 | 6.67 | 99.9 | 1 | ||
TM-SITE | 97.02 | 6.67 | 99.51 | 7.08 | ||
PO4 | 8 | TargetCom | 97.68 | 4.17 | 99.59 | 4.52 |
COACH | 97.54 | 05 | 99.43 | 2.9 | ||
S-SITE | 97.81 | 0 | 99.76 | −0.36 | ||
TargetSeq | 98.08 | 13.39 | 99.66 | 12.98 | ||
COFACTOR | 97.91 | 0 | 99.86 | −0.17 | ||
TM-SITE | 98.05 | 0 | 1 | 0 | ||
ATP | 4 | TargetCom | 93.92 | 5 | 97.14 | 1.38 |
COACH | 93.92 | 5 | 97.14 | 1.38 | ||
S-SITE | 96.42 | 0 | 1 | 0 | ||
TargetSeq | 97.32 | 27.08 | 99.85 | 33.79 | ||
COFACTOR | 96.42 | 0 | 1 | 0 | ||
TM-SITE | 93.69 | 5 | 96.9 | 1.19 | ||
HEME | 9 | TargetCom | 92.74 | 16.7 | 99.21 | 25.02 |
COACH | 91.8 | 03.98 | 99.3 | 07.3 | ||
S-SITE | 92.43 | 14.9 | 99.2 | 17.25 | ||
TargetSeq | 89.54 | 15.47 | 95.68 | 11.59 | ||
COFACTOR | 92.12 | 0 | 1 | 0 | ||
TM-SITE | 92.12 | 0 | 1 | 0 |