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Table 3 Experimental data and classification results according to TFClass

From: Feature-based classification of human transcription factors into hypothetical sub-classes related to regulatory function

  

Total

Experimental

Classified

Average p-value

TFClass

Code

#TFs

#TFs

P

S

M+

M-

#TFs

P

S

M+

M-

All

Margin

Uncharacterized

0.0

6

0

0

0

0

0

6

0

5

1

0

0.682

0.027

NonO domain factors

0.2

2

0

0

0

0

0

2

0

2

0

0

0.679

0.022

Leucine-rich repeat proteins

0.3

1

0

0

0

0

0

1

0

1

0

0

0.679

0.022

NFX1-type putative zf factors

0.4

3

0

0

0

0

0

3

1

2

0

0

0.673

0.016

bZIP

1.1

54

25

2

9

3

11

29

10

9

0

10

0.720

0.150

bHLH

1.2

84

29

1

23

3

2

55

0

55

0

0

0.943

0.539

bHSH

1.3

4

1

1

0

0

0

3

3

0

0

0

0.759

0.128

Nuclear receptors with C4 zfs

2.1

47

47

1

1

45

0

0

0

0

0

0

-

-

Other C4 zfs

2.2

17

4

0

0

1

3

13

0

0

0

13

0.738

0.056

Three-zf Kruppel-related factors

2.3.1

26

5

4

1

0

0

21

21

0

0

0

0.958

0.273

Other factors with 3 adjacent zf

2.3.2

15

0

0

0

0

0

15

12

0

3

0

0.773

0.203

More than 3 adjacent zf

2.3.3

327

12

6

1

4

1

315

201

0

114

0

0.862

0.213

Factors multiple dispersed zf

2.3.4

103

5

1

2

1

1

98

35

58

5

0

0.765

0.086

DM-type intertwined zf factors

2.5

6

0

0

0

0

0

6

0

0

6

0

0.704

0.166

CXXC zf factors

2.6

7

0

0

0

0

0

7

0

0

7

0

0.704

0.112

C2HC zf factors

2.7

8

0

0

0

0

0

8

0

0

8

0

0.704

0.116

C3H zf factors

2.8

2

0

0

0

0

0

2

0

0

2

0

0.704

0.116

C2CH THAP-type zf factors

2.9

1

0

0

0

0

0

1

0

0

1

0

0.704

0.084

Homeo domain factors

3.1

198

198

0

0

3

195

0

0

0

0

0

-

-

Paired box factors

3.2

9

5

0

1

1

3

4

0

1

2

1

0.735

0.181

Fork head

3.3

56

56

2

3

1

50

0

0

0

0

0

-

-

Heat shock factors

3.4

5

0

0

0

0

0

5

0

5

0

0

0.683

0.120

Tryptophan cluster factors

3.5

50

34

23

3

7

1

16

0

0

16

0

0.937

0.264

TEA domain factors

3.6

4

1

0

0

1

0

3

0

0

3

0

0.808

0.152

ARID domain factors

3.7

12

1

0

0

0

1

11

1

10

0

0

0.631

0.012

HMG domain factors

4.1

41

19

0

0

2

17

22

0

0

0

22

0.741

0.338

Het. CCAAT-binding factors

4.2

4

2

2

0

0

0

2

2

0

0

0

0.817

0.357

MADS box factors

5.1

5

2

0

0

0

2

3

0

0

0

3

0.650

0.014

SAND domain factors

5.3

7

3

1

0

2

0

4

0

0

4

0

0.906

0.304

RHR factors

6.1

21

3

0

1

2

0

18

0

0

18

0

0.907

0.125

STAT domain factors

6.2

7

0

0

0

0

0

7

0

0

7

0

0.777

0.076

p53 domain factors

6.3

3

0

0

0

0

0

3

0

0

3

0

0.777

0.062

Runt domain factors

6.4

3

0

0

0

0

0

3

0

0

3

0

0.777

0.062

T-Box factors

6.5

16

1

0

1

0

0

15

0

12

3

0

0.814

0.071

Grainyhead domain factors

6.7

4

0

0

0

0

0

4

0

0

4

0

0.777

0.122

SMAD/NF-1 DBD factors

7.1

8

1

1

0

0

0

7

3

4

0

0

0.761

0.211

GCM domain factors

7.2

2

1

0

1

0

0

1

0

1

0

0

0.844

0.268

TATA-binding proteins

8.1

2

1

0

0

1

0

1

0

0

1

0

0.805

0.171

AT hook factors

8.2

2

1

0

0

0

1

1

0

1

0

0

0.634

0.001

Cold-shock domain factors

9.1

3

0

0

0

0

0

3

0

3

0

0

0.679

0.022

Sum

-

1175

457

45

47

77

288

718

289

169

211

49

  
  1. The results are shown for Pioneers (P), Settlers (S), positive Migrants (M+) and negative Migrants (M-)