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Table 5 Enriched or depleted features in significantly regulated TFs

From: Feature-based classification of human transcription factors into hypothetical sub-classes related to regulatory function

Class

Up

  

Down

  

Term

Obs/Exp

P(Benj)

Term

Obs/Exp

P(Benj)

Pioneers

Ets

9/0

2.2e-07

   

zf-H2C2_2

25/9

1.2e-05

zf-H2C2_2

69/18

1.0e-08

   

KRAB

36/10

1.1e-08

   

zf-H2C2_4

14/3

9.2e-05

Settlers

HLH

20/1

2.5e-09

HLH

18/2

3.9e-09

   

Ubiquitination

33/18

4.7e-04

   

Sumoylation

11/5

4.6e-02

   

PPI

5/11

4.9e-02

Migrants+

PPI

20/11

6.1e-03

   
   

Hormone_recep

19/1

6.6e-09

   

zf-C2H2

33/8

7.3e-09

   

zf-C4

19/1

9.7e-09

Migrants-

   

HMG_box

11/1

1.1e-05

   

zf-H2C2_2

1/14

3.6e-04

   

Homeobox

17/5

9.3e-04

   

Methylation

16/8

4.2e-02

All

Ubiquitination

74/49

5.4e-05

Ubiquitination

112/90

8.4e-03

bZIP_1

12/2

1.8e-04

   

HLH

20/6

2.7e-04

   

Ets

10/2

1.1e-03

   

Sumoylation

27/15

5.1e-03

   

PPI

50/37

1.8e-02

   

Phosphorylation

144/136

4.9e-02

Phosphorylation

269/252

7.7e-04

   

zf-H2C2_2

113/63

5.7e-08

   

zf-C2H2

56/29

6.0e-05

   

zf-C4

20/6

4.8e-05

   

Hormone_recep

20/6

8.4e-05

   

KRAB

58/34

8.9e-04

   

zf-C2H2_4

24/10

2.5e-03

  1. Only features with at least 9 occurrences (as observed for enrichments or expected for depletions) are listed. Depleted features are highlighted in italics. The All category shows enrichment analysis of all significantly up- or down-regulated genes, independent of functional classification