Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23

Table 2 Summary of clusters

Cluster	Name	# Members	Avg Seq Id	Avg Length	Scaffold
1	Knottin CSαβ I	115	21.8	38	2crdA
2	Knottin Classic ICK	98	23.4	24	2jtbA
3	Insulin	58	42.4	23	3gkyC
4	Small Conotoxin	52	24.9	12	1e76A
5	Knottin Cyclotide ICK	48	30.9	30	3e4hA
6	Small Hairpin	42	15.9	16	1wo0A
7	EGF-like Hairpins	39	17.0	19	2oqjL
8	Medium Conotoxin	35	21.0	17	2uz6K
9	α-Defensin	30	53.4	31	3lo2B
10	β-Defensin	25	51.1	37	2nlsA
11	Large Hairpin	22	21.5	17	1gm2A
12	Crambin	19	56.8	46	1orlA
13	Helix-Loop-Helix	19	12.2	34	1bzbA
14	LDL Receptor	17	30.4	39	2kriB
15	Knottin CSαβ II	12	19.7	29	1du9A
16	PMP Inhibitor	11	59.0	35	2f91B
17	TNF Receptor	11	42.6	39	1xu2R
18	Large Conotoxin	10	24.6	19	1tckA
19	Tryptase Inhibitor	10	42.2	39	2kmoA
20	Anti-microbial Peptide	9	49.2	30	1mmcA

Clusters are sorted by number of members. Name: Manually assigned name, derived from the most frequent SCOP fold assignment for each cluster. Avg Seq Id: Average pairwise sequence identity of all DRPs in the cluster. Avg Length: Average sequence length of all DRPs in the cluster, derived from the sequence resolved in the PDB structure. Scaffold: Selected representative for the cluster

ISSN: 1471-2105