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Fig. 5 | BMC Bioinformatics

Fig. 5

From: Most of the tight positional conservation of transcription factor binding sites near the transcription start site reflects their co-localization within regulatory modules

Fig. 5

An RM enriches the intersection of two gene groups. A hypothetical RM (indicated by dotted black rounded rectangles) is illustrated, similar to an RM in Fig. 1. The RM contains three TFBSs, corresponding to an orange rectangle, a green triangle, and a red circle. The “red circular TF” yields motif scores (vertical red lines) corresponding to the maximal segment and motif cluster shown in Fig. 2. Like the red circular TF, the green triangular TF yields its own motif scores (vertical green lines). Not every “red” or “green” motif corresponds to a TFBS in the RM, but nonetheless, the RM enriches the intersection of the two cluster gene groups (horizontal lines, either red dashed or green dotted)

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