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Fig. 3 | BMC Bioinformatics

Fig. 3

From: SPECtre: a spectral coherence-­based classifier of actively translated transcripts from ribosome profiling sequence data

Fig. 3

Examples of SPECtre results and runtime comparison to RiboTaper. a SPECtre posterior probability profile (shaded gray) and normalized P­site adjusted read coverage (black bars) over the transcript structure of RCC1­201. Solid, horizontal black line represents the translational threshold as calculated by SPECtre at a false discovery rate of 0.05. Arrow indicates position of annotated translational start site. Thin black boxes (left to right) denote the 5′UTR and 3′UTR, respectively, with CDS (thick black box) in between. b SPECtre posterior probability profile (as above) over the transcript structure of MIEF1. Thin, black boxes under transcript structure denote two uORFs previously identified by RiboTaper analysis. c Scatter plot of SPECtre and log2(RiboTaper) scores over assessed ORFs. d Comparison of SPECtre (left) and RiboTaper (right) total compute time, in hours

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BMC Bioinformatics

ISSN: 1471-2105

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