Fig. 4
From: Statistical ensemble of gene regulatory networks of macrophage differentiation
M2-polarised response. The effect of injecting IL-10 after a bacterial infection is clearly shown is panel a in two representative cases of possible outcome; in some cases (43% of total stochastic simulations performed) IL-10 dampens the immune response. Panel b shows the average population kinetics of the two macrophage sub-types as well as the injected IL-10 concentration (error-bars show standard deviation over a number of stochastic simulations). This plot demomstrates that IL-10 downregulates immune reponse by promoting M2 differentiation. Similarly, panel c shows T-helper cell sub-types