Skip to main content
# Table 1 Various N-Benzothiazolyl-2-Phenyl Acetamide derived compounds with substitutions at the six substitution sites, percentage inhibition showed at a concentration of 10 μM and their IC50 values

From: Novel group-based QSAR and combinatorial design of CK-1δ inhibitors as neuroprotective agents

Compound | R1 | R2 | R3 | R4 | R5 | R6 | IC |
---|---|---|---|---|---|---|---|

1 | H | Me | H | Cl | H | H | 0.083 |

2 | H | CF | H | Cl | H | H | 0.023 |

3 | H | OMe | H | Cl | H | H | 0.53 |

4 | H | OCF | H | Cl | H | H | 0.54 |

5 | H | OEt | H | Cl | H | H | 1.21 |

6 | H | CF | Cl | H | H | H | 0.068 |

7 | H | OMe | Cl | H | H | H | 9.71 |

8 | H | OEt | Cl | H | H | H | 17.43 |

9 | H | CF | H | H | Cl | H | 0.065 |

10 | H | OMe | H | H | Cl | H | 0.75 |

11 | H | OEt | H | H | Cl | H | 1.11 |

12 | H | Br | OMe | H | H | H | 0.26 |

13 | H | Cl | OMe | H | H | H | 0.32 |

14 | H | F | OMe | H | H | H | 1.17 |

15 | H | Me | OMe | H | H | H | 0.29 |

16 | H | OMe | OMe | H | H | H | 2.22 |

17 | H | OCF | OMe | H | H | H | 0.62 |

18 | H | OEt | OMe | H | H | H | 5.76 |

19 | H | CF | H | OMe | H | H | 0.042 |

20 | H | OMe | H | OMe | H | H | 0.42 |

21 | H | OEt | H | OMe | H | H | 0.99 |

22 | H | CF | H | CF | H | H | 0.087 |

23 | H | CF | H | H | OMe | H | 0.033 |

24 | H | OMe | H | H | OMe | H | 0.57 |

25 | H | OEt | H | H | OMe | H | 1.09 |

26 | H | H | H | H | H | H | 0.33 |

27 | H | CF | H | H | H | H | 0.047 |

28 | H | CF | H | Cl | Cl | H | 0.056 |

29 | H | OMe | H | Cl | Cl | H | 1.24 |

30 | H | OEt | H | Cl | Cl | H | 3.43 |

31 | H | OCF | H | Cl | Cl | H | 0.59 |

32 | H | CF | OMe | H | H | OMe | 0.19 |

33 | H | OCF | H | OMe | OMe | OMe | 0.079 |

34 | H | OMe | H | OMe | OMe | OMe | 1.12 |

35 | H | OEt | H | OMe | OMe | OMe | 1.43 |

36 | H | CF | H | OMe | OMe | OMe | 0.015 |

37 | H | H | H | Cl | H | H | 0.85 |