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Table 1 Various N-Benzothiazolyl-2-Phenyl Acetamide derived compounds with substitutions at the six substitution sites, percentage inhibition showed at a concentration of 10 μM and their IC50 values

From: Novel group-based QSAR and combinatorial design of CK-1δ inhibitors as neuroprotective agents

Compound R1 R2 R3 R4 R5 R6 IC50
1 H Me H Cl H H 0.083
2 H CF3 H Cl H H 0.023
3 H OMe H Cl H H 0.53
4 H OCF3 H Cl H H 0.54
5 H OEt H Cl H H 1.21
6 H CF3 Cl H H H 0.068
7 H OMe Cl H H H 9.71
8 H OEt Cl H H H 17.43
9 H CF3 H H Cl H 0.065
10 H OMe H H Cl H 0.75
11 H OEt H H Cl H 1.11
12 H Br OMe H H H 0.26
13 H Cl OMe H H H 0.32
14 H F OMe H H H 1.17
15 H Me OMe H H H 0.29
16 H OMe OMe H H H 2.22
17 H OCF3 OMe H H H 0.62
18 H OEt OMe H H H 5.76
19 H CF3 H OMe H H 0.042
20 H OMe H OMe H H 0.42
21 H OEt H OMe H H 0.99
22 H CF3 H CF3 H H 0.087
23 H CF3 H H OMe H 0.033
24 H OMe H H OMe H 0.57
25 H OEt H H OMe H 1.09
26 H H H H H H 0.33
27 H CF3 H H H H 0.047
28 H CF3 H Cl Cl H 0.056
29 H OMe H Cl Cl H 1.24
30 H OEt H Cl Cl H 3.43
31 H OCF3 H Cl Cl H 0.59
32 H CF3 OMe H H OMe 0.19
33 H OCF3 H OMe OMe OMe 0.079
34 H OMe H OMe OMe OMe 1.12
35 H OEt H OMe OMe OMe 1.43
36 H CF3 H OMe OMe OMe 0.015
37 H H H Cl H H 0.85