From: Novel group-based QSAR and combinatorial design of CK-1δ inhibitors as neuroprotective agents
Complex | Residues involved in hydrophobic interactions | Residues involved in hydrogen bonding |
---|---|---|
CK-1δ-CHC | Ile23, Met82, Leu84, Leu85, Gly86, Pro87, Asp91, Leu135, Ile148, Asp149 | Lys38, Glu52, Tyr56 |
CK-1δ-DHC | Gly21, Ile23, Ala36, Met82, Leu85, Gly86, Pro87, Phe95, Lys130, Asn133, Leu135, Ile148, Asp149 | Lys38, Asp91 |