TY - JOUR AU - Scala, Giovanni AU - Affinito, Ornella AU - Palumbo, Domenico AU - Florio, Ermanno AU - Monticelli, Antonella AU - Miele, Gennaro AU - Chiariotti, Lorenzo AU - Cocozza, Sergio PY - 2016 DA - 2016/11/25 TI - ampliMethProfiler: a pipeline for the analysis of CpG methylation profiles of targeted deep bisulfite sequenced amplicons JO - BMC Bioinformatics SP - 484 VL - 17 IS - 1 AB - CpG sites in an individual molecule may exist in a binary state (methylated or unmethylated) and each individual DNA molecule, containing a certain number of CpGs, is a combination of these states defining an epihaplotype. Classic quantification based approaches to study DNA methylation are intrinsically unable to fully represent the complexity of the underlying methylation substrate. Epihaplotype based approaches, on the other hand, allow methylation profiles of cell populations to be studied at the single molecule level. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-016-1380-3 DO - 10.1186/s12859-016-1380-3 ID - Scala2016 ER -