From: Predicting the recurrence of noncoding regulatory mutations in cancer
Category | Mean decrease accuracy (%) | ||
---|---|---|---|
p < 5 × 10−6 | Recurrence ≥ 4 | ||
Target Gene Features | HumanNet.CGS_L1 | 5.26 | 4.85 |
HumanNet.CGS_L2 | 6.78 | 6.42 | |
InteractNet.CGS_L1 | 10.86 | 9.52 | |
InteractNet.CGS_L2 | 10.16 | 10.84 | |
RegNet.DEG_score | 10.88 | 10.79 | |
DEG_score | 9.72 | 9.51 | |
Binding TF Features | HumanNet.CGS_L1 | 4.91 | 2.92 |
HumanNet.CGS_L2 | 4.57 | 3.23 | |
InteractNet.CGS_L1 | 2.67 | 2.66 | |
InteractNet.CGS_L2 | 4.99 | 7.40 | |
RegNet.DEG_score | 6.68 | 3.61 | |
DEG_score | 4.77 | 6.13 | |
TFBS Scores | diff_Log_Pval_FIMO | 2.59 | 2.53 |
avg_Log_Pval_FIMO | 8.04 | 7.48 | |
Gain_or_Loss | 1.57 | 0.37 | |
Cancer Cell Epigenetic Signals | DnaseSig | 17.34 | 16.94 |
H3K27ac | 8.95 | 7.62 | |
H3K27me3 | 11.94 | 10.23 | |
H3K36me3 | 7.50 | 5.23 | |
H3K4me3 | 9.45 | 7.99 | |
H3K9me3 | 10.19 | 9.02 | |
Genetic Signals | Distance.to.GWAS | 15.82 | 11.00 |
Early.to.late_Rate | 7.09 | 7.00 | |
PhastCons | 1.26 | −0.18 | |
Original Cell Epigenetic Signals | DnaseSig | 17.90 | 17.05 |
H3K27ac | 9.45 | 9.59 | |
H3K27me3 | 5.91 | 7.26 | |
H3K36me3 | 15.69 | 7.98 | |
H3K4me1 | 11.50 | 9.69 | |
H3K4me2 | 7.97 | 8.78 | |
H3K4me3 | 7.88 | 7.02 | |
H3K79me2 | 6.33 | 4.98 | |
H3K9ac | 7.79 | 8.79 | |
H3K9me3 | 4.83 | 13.12 | |
H4K20me1 | 8.38 | 7.44 |