Fig. 4From: Robust differential expression analysis by learning discriminant boundary in multi-dimensional space of statistical attributesEvaluates RNA-seq differential expression analysis methods using simulated data (6 vs. 6; G 500500 ). Methods are listed along the x-axis. The red bars indicate the average true FDRs (refer to the left y-axis). The horizontal dashed line across the figure marks the target FDR. The blue bars indicate the average number of the detected true DEFs (refer to the right y-axis). The 90% confidence intervals of the detected DEFs are marked except for those whose true FDRs exceed the target FDR by 10%. a target FDR < 0.01. b target FDR < 0.05. The true FDRs of DCT+R+NB do not exceed the corresponding target FDRs. DCT+R+NB was the most powerful among those able to effectively control the FDR (see main text for more discussions)Back to article page