Comparison of different statistical approaches for urinary peptide biomarker detection in the context of coronary artery disease

Table 7 Multi-centre cohort classifiers built from all 5616 peptides and selected features using f-score

Cohort	Size (cases/controls)			All peptides (5616)		Selected peptides
Cohort	Total	Discovery	Validation	AUC (discovery)	Accuracy (validation)	Peptide number	AUC (discovery)	Accuracy (validation)
CAD	101/96	66/66	35/30	0.750	60%	148	0.871	64.6%
AMI in 0–5 y	113/113	75/75	38/38	0.653	63.2%	154	0.873	73.7%
AMI in 5–11 y	144/171	75/75	69/96	0.653	52.1%	154	0.873	61.2%
CVD	214/208	141/140	73/68	0.709	61.7%	651	0.805	71.6%

y years, AUC area under the curve of a Receiver Operating Characteristic (ROC) curve analysis

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