TY - JOUR AU - Rawi, Reda AU - Mall, Raghvendra AU - Kunji, Khalid AU - El Anbari, Mohammed AU - Aupetit, Michael AU - Ullah, Ehsan AU - Bensmail, Halima PY - 2016 DA - 2016/12/15 TI - COUSCOus: improved protein contact prediction using an empirical Bayes covariance estimator JO - BMC Bioinformatics SP - 533 VL - 17 IS - 1 AB - The post-genomic era with its wealth of sequences gave rise to a broad range of protein residue-residue contact detecting methods. Although various coevolution methods such as PSICOV, DCA and plmDCA provide correct contact predictions, they do not completely overlap. Hence, new approaches and improvements of existing methods are needed to motivate further development and progress in the field. We present a new contact detecting method, COUSCOus, by combining the best shrinkage approach, the empirical Bayes covariance estimator and GLasso. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-016-1400-3 DO - 10.1186/s12859-016-1400-3 ID - Rawi2016 ER -