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Fig. 3 | BMC Bioinformatics

Fig. 3

From: PCAN: phenotype consensus analysis to support disease-gene association

Fig. 3

Assessing a gene's relevance for a condition by applying a pathway consensus approach. a Each gene, which is known to be involved in at least one genetic disorder, is associated to the corresponding HP terms. These HP terms are compared to those related to the disease of interest by computing a symmetric semantic similarity score. b The scores of all genes related to the gene of interest are compared to scores for all known Mendelian disease genes. Here the gene candidate is in yellow and its direct neighbors are in blue. Nodes surrounded in red correspond to genes with a high semantic similarity score for the disease under focus

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