Structural prediction of the interaction of the tumor suppressor p27KIP1 with cyclin A/CDK2 identifies a novel catalytically relevant determinant

Table 1 Information on human CDK2 substrates confirmed by in vivo experiments

Index	Protein	UniProtKB	P + 0 site	Site sequence	Ref.
1	ATRIP	Q8WXE1	S224	VSHVSPRKNPSV	[50]
2	BRCA1	P38398	S1497	VERSSPSKCPSL	[51]
3	CDKN2D	P55273	S76	SGTSPVHDAAR	[52]
4	CROCC iso2	Q5TZA2-2	S763	PVPGSPARDAPA	[53]
5	Ctip	Q99708	T847	IPPNTPENFWEV	[54]
6	DLG1	Q12959	S158	HSHISPIKPTEA	[55]
7	DLG1	Q12959	S443	QTPASPARYSPV	[55]
8	EZH2	Q15910	T345	ERIKTPPKRPGG	[56]
9	FOXM1 iso2	Q08050-2	T596	PISSTPSKSVLP	[57]
10	FOXO1A	Q12778	S249	KSGKSPRRRAAS	[58]
11	HIRA	P54198	T555	SVLTTPSKIEPM	[59]
12	HR6A	P49459	S120	PNPNSPANSQAA	[60]
13	ID3	Q02535	S5	MKALSPVRGCYE	[61]
14	ING5	Q8WYH8	T152	EEEDTPKKKKHK	[62]
15	LIG3	P49916	S210	GQVTSPVKGASF	[63]
16	ORC2	Q13416	T116	ELAKTPQKSVSF	[64]
17	ORC2	Q13416	T226	VGKETPSKRMKR	[64]
18	p27	P46527	T187	SVEQTPKKPGLR	[65]
19	p63	Q9H3D4	T491	RNALTPTTIPDG	[66]
20	p73	O15350	T86	ASPYTPEHAASV	[67]
21	PELP1	Q8IZL8	S991	PPPESPPKVQPE	[68]
22	PLZF	Q05516	S197	LSAMSPTKAAVD	[69]
23	PLZF	Q05516	T282	EGPGTPTRSSVI	[69]
24	PTPN2 iso2	P17706-2	S304	AFDHSPNKIMTE	[70]
25	RbBP1	P29374	S864	LGQSSPEKKIRI	[71]
26	RbBP1	P29374	S1007	FSVASPLTLSQD	[71]
27	RPL12	P30050	S38	PLGLSPKKVGDD	[72]
28	SIRT2	Q8IXJ6	S368	STSASPKKSPPP	[49]
29	Smad3	P84022	T8	ILPFTPPIVKRL	[73]
30		P84022	T179	NIPETPPPGYLS
31		P84022	S213	PNPMSPAHNNLD
32	SMRT	Q9T618	S1259	IGEDSPSRLDRG	[74]
33		Q9T618	T1463	ITQGTPLKYDTG
34		Q9T618	S1487	SLIGSPGRTFPP
35	NBS1	Q9NX02	S432	NYQLSPTKLPSI	[75]

ISSN: 1471-2105