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Table 4 SVM classifier performance at different stages of the embryonic development tree

From: MicroRNA based Pan-Cancer Diagnosis and Treatment Recommendation

Stage I classifier

Stage II classifier

Stage III classifier

Subtype

Sensitivity

Specificity

Subtype

Sensitivity

Specificity

Subtype

Sensitivity

Specificity

Endoderm

0.99

1

GI Tube

0.99

0.99

Thymus

0.98

1

Lung

0.98

1

Pancreas

0.96

1

GI Tract

0.98

1

Liver

0.98

1

Thyroid

1

1

Mesoderm

0.99

1

Lateral Plate Mesoderm

0.97

1

Adipose

0.98

1

Lymph

0.96

1

Heart

0.98

1

Intermediate Mesoderm

0.99

1

Reproductive

0.99

1

Urinary

0.98

1

Kidney

0.99

1

Ectoderm

1

1

Neural Ectoderm/Neural Tube

1

1

Brain

1

1

Neural Crest

0.99

1

Peripheral Nervous System

0.99

1

Surface Ectoderm

1

1

Epidermis

1

1

  1. Climbing up the embryonic development tree, SVM classifiers were built at each stage to classify the cancers at different granularities. Stage 4 identifies the actual cancer. Stage III classifier can classify the cancers at the tissue/organ level. At Stage I, the cancer is classified as belonging to one of the germ layers