Fig. 1From: Variational inference for rare variant detection in deep, heterogeneous next-generation sequencing dataGraphical model. a Graphical model representation of the model. b Graphical model representation of the variational approximation to approximate the posterior distribution. Observed random variables are shown as shaded nodes and latent random variables are unshaded. The object of inference for the variational EM algorithm is the joint distribution p(μ,θ|r,n)Back to article page