From: MC-GenomeKey: a multicloud system for the detection and annotation of genomic variants
 | STORMseq | Atlas2 | Simplex | WEP | GenomeKey | MC-GenomeKey |
---|---|---|---|---|---|---|
Quality | - | - | fastx-toolkit | ngs-qc toolkit + fastqc | fastx-toolkit | fastx-toolkit |
Mapping | BWA | - | BWA | BWA | BWA | BWA |
Variant Calling | GATK | Logistic Regression Model | GATK | GATK | GATK | GATK |
Annotation | VEP (variant effect predictor) | - | Annovar | Annovar | Annovar | Annovar |
Deployment | AWS EC2 | AWS EC2 | AWS EC2 | Web Service | AWS EC2 | AWS, Google Cloud, Amazon, OpenStack based |
Web Interface | Yes | Yes | No | Yes | Yes | Yes |
Multiple samples in one run | No | No | No | No | Yes | Yes |
Parallelization technique | split by chromosome | - | - | NA | split by chromosome + split by read group id | split by chromosome + split by read group id + more split by sub-group ID and sub-chromosomes |
Workflow Engine | Python Scripts | - | JClusterService | Scripts | Cosmos | Cosmos |
Modularity | No | - | No | No | Yes | Yes |
Use of Heterogeneousa cluster | No | No | No | NA | No | Yes |
Failure-handling+ Mechanisms | No | No | No | No | No | Yes |
Use of Spot Instances | No | No | No | NA | No | Yes |