Fig. 1
From: Pysim-sv: a package for simulating structural variation data with GC-biases
The workflow of Pysim-sv. Component 1 simulates a personal genome by introducing genomic variations to a given reference genome. Component 2 generates tumor genomes by simulating aneuploidy and somatic variations. Subclones are iteratively generated. Component 3 generates HTS reads, mixes reads from different tumor/normal genomes and introduces GC-bias