Fast and accurate mutation detection in whole genome sequences of multiple isogenic samples with IsoMut

BMC Bioinformatics

Table 1 Comparison of runtimes of different tools with all available resources

Tool	12 cores				Single core
Tool	Number of parallel processes	Runtime	Equivalent runtime on 1 Gb genome	Runtime relative to IsoMut	Runtime	Runtime relative to IsoMut
IsoMut	12	1 min 24 s	4 h 56 min	1	7 min	1
VarScan 2	5–6	16 min	2 days 8 h	11	1 h 20 min	11
MuTect	6–7	1 h 7 min	9 days 20 h	48	4 h 55 min	42
MuTect2	4–5	4 h	35 days 5 h	171	21 h 6 min	178

Table of the runtime comparison of different mutation detection software using a computer with 23 GB memory and 12 cores or a single core only. The tools were run on the 4.735 Mb chicken chromosome 28 using the 30-sample dataset used throughout this study

ISSN: 1471-2105